At Arvelle, we are committed to helping those affected by epilepsy. We aspire to do this by making innovative therapies available to more patients.
Epilepsy is defined by any of the following conditions:5
- At least two unprovoked seizures occurring >24 hours apart
- One unprovoked seizure and a high chance of further seizures
- Diagnosis of an epilepsy syndrome
Prevalence of epilepsy
Up to 2% of people worldwide have epilepsy, making it one of the most common serious neurological diseases.6
ILAE classifies epilepsy into 4 types:10
Focal epilepsy is characterised by epileptic seizures that start in one hemisphere of the brain.
Generalised epilepsy is characterised by seizures that originate in both hemispheres of the brain simultaneously.
combined generalised and focal epilepsy
Combined generalised and focal epilepsy is when patients experience both focal and generalised seizures (common examples in which both types of seizures occur are Dravet syndrome and Lennox-Gastaut syndrome).
If a person has epilepsy and experiences seizures, but it is not possible to determine where the seizure originates in the brain, doctors categorise it as unknown epilepsy.
The effects of epilepsy
An epilepsy diagnosis can affect many aspects of a person’s life, including physical, psychological and social challenges that impact self-esteem, family, relationships, leisure, work, career prospects and the ability to drive.3, 13
People with epilepsy whose seizures are poorly controlled often experience related medical conditions, social stigmatisation, psychological dysfunction and reduced quality of life.14, 15
Thankfully, successful treatment may reduce or even eliminate many of these negative effects.
There is a recognised need for more effective treatments which can improve patient lives.14, 17, 20
Reduced probability of treatment success
With every unsuccessful ASM, the probability of seizure freedom** diminishes significantly.1
* Defined by ILAE as failure of two appropriately selected, used and
tolerated anti-seizure medication regimens.
** Defined as being free from seizures for ≥12 months.1